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- Focus on fungal oxidoreductases for infectious disease drug targets - “The atomic structure of proteins provides an intimate insight into these magnificent macromolecules. This knowledge is crucial to truly understand how they function; whether it is to answer a burning question or to manipulate them – either to enhance if their reactions are desirable, or to inhibit if they are harmful.” Prof. Dirk Opperman, University of … Read more Focus on fungal oxidoreductases for infectious disease drug targets
- New generation solutions to Neglected Tropical Diseases and Nosocomial ESKAPE Infections - “Africa is a bank when it comes to diseases. The beauty of the GCRF START grant is that it offers us the opportunity to deal with these challenges in Africa, while enabling international collaboration and access to amazing synchrotron facilities with world class results.” Dr Ikechukwu Anthony Achilonu, Protein Structure-Function Research Unit (PSFRU), University of the Witwatersrand, South Africa Neglected Tropical Diseases (NTD’s) and Antimicrobial Resistance (AMR) are major challenges threatening the world’s sustainability and development efforts across the spectrum of the UN’s Sustainable Development Goals, causing millions of … Read more New generation solutions to Neglected Tropical Diseases and Nosocomial ESKAPE Infections
- SA women take the lead in structural biology - A team of researchers from the University of Cape Town (UCT) and University of the Free State (UFS) has achieved a remarkable feat in the field of structural biology by determining the structure of an enzyme that could be a key component in producing valuable commodity chemicals in greener, sustainable processes. Known as cytochrome P450 … Read more SA women take the lead in structural biology
- Double first! First synchrotron user from the University of Zululand solves partial structure of the Schistosomiasis (Bilharzia) G4LZI3 universal stress protein - In a ‘double first’, Dr Priscilla Masamba, has become the first University of Zululand student to use the UK’s National Synchrotron Light Source, Diamond, and solve the partial structure of a protein from Schistosoma mansoni. With access to the synchrotron made possible by GCRF START, Priscilla employed sophisticated robotic instruments and macromolecular X-ray crystallography techniques … Read more Double first! First synchrotron user from the University of Zululand solves partial structure of the Schistosomiasis (Bilharzia) G4LZI3 universal stress protein
- Structural biology – Improvements in health - The need for health improvement on the African continent continues to be a pressing issue, and START’s emphasis will be on diseases such as HIV-AIDS, malaria, tuberculosis, and African horse sickness that are devastating to human and animal populations. The structural biology strand of START research will support scientists in finding and developing cures by … Read more Structural biology – Improvements in health
- The START of great things! - Visualising the structure of an intact helical filament at close-to-atomic resolution for the first time “We are seeing critical scientific discoveries and the emergence of a new generation of experts that have resulted directly from our training programmes in advanced methods and the use of synchrotron facilities and tools.” Dr Gwyndaf Evans, START Principal Life … Read more The START of great things!